Current Position: English/中文

•Vice President, Academician/副院長，院士

•Distinguished Research Fellow, /特聘研究員

•Institute of Biomedical Sciences/生物醫學研究所

•Academia Sinica/中央研究院

Education/Training:

•1974-1978 B.S. Dept. of Biology, Tunghai University, Taiwan

•1984-1988 M.Ph./Ph.D. Dept. of Human Genetics, Yale University, USA

EDUCATION

•1983 M.A., Ph.D., in Biochemistry (Mentor: Pieter C. Winsink, Ph.D.), Brandeis University, Waltham, U.S.A.

•1977 M.S., in Biochemistry, National Taiwan University, Taipei, Taiwan

•1973 B.S., in Chemistry, National Taiwan University, Taipei, Taiwan

Position and selected service to advisory boards

•President, China Medical University Taichung, Taiwan 02/18/2019- present中國醫藥大學校長

•Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010−02/17/19德州大學安德森癌症中心基礎科學研究副院長

•Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2000−02/17/19德州大學安德森癌症中心分子細胞腫瘤系主任

•Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008−02/17/19德州大學安德森癌症中心生物信號通路中心主任

•Professor, The University of Texas M.D. Anderson Cancer Center, TX, 09/94-02/17/19 德州大學安德森癌症中心教授

•Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2003−02/17/19德州大學安德森癌症中心Ruth Legett Jones傑出講席教授

•President (International), Society of Chinese Bioscientists in America, 2004−2005美洲華人生物科學學會會長

•Member, Board of Directors, China Medical University and Hospital Health System, Taiwan, 2004-01/2019. 中國醫藥大學及附屬醫院 董事會董事

•Honorary Director, Center for Molecular Medicine, China Medical University and Hospital, Taichung, Taiwan, 9/2006−present. 中國醫藥大學及附屬醫院分子醫學中心榮譽主任

•Member, Cancer Research Advisory Board, Ministry of Health and Welfare of Taiwan, April 10, 2014 to December 31, 2017. 衛生福利部癌症研究顧問委員會委員

•Member, Scientific Advisory Board, Life Sciences Institute, Zhejiang University, Hengzhou, China, 2014- present.浙江大學生命科學學院科學顧問委員會委員

•Member, Advisory Committee, University of Macau, Macau, China, July 2015-2016澳門大學顧問委員會委員

•Member, Selection Committee, Pezcoller Foundation-AACR Award, 2016 Pezcoller基金會AACR獎評選委員會委員

•Member, External Advisory Board, The University of Kansas Cancer Center, 2017-堪薩斯大學癌症中心校外顧問委員會委員

As President of China Medical University (After February 2019)

•Chairman, Spring Academic Lectures, Formosan Medical Association台灣醫學會 2022. 111年春季學術演講會會長

•Member, Organizing Committee of the Cancer Symposium, Ministry of Health and Welfare. 2022 衛生福利部癌症研討會組織委員會成員

•Member, Scientific Review on Institute of Molecular and Genomic Medicine, 2021. NHRI國家衛生研究院分子與基因醫學研究所(分基所)學術評鑑委員

•Member, Selection Committee for the President of NHRI2021-2022. 國家衛生研究院院長遴選委員會委員

•Member of Academic Advisory Committee (AAC), Biomedical Translation Research Center (BioTReC), National Biotechnology Research Park (NBRP), Academia Sinica, Taiwan 2021-2025中央研究院生醫轉譯中心及國家生技研究園區學術顧問委員會成員

•Member, Advisory Committee, National Taiwan University. 2021台灣大學學術顧問委員會委員

•16th Council Member, Taiwan Bio-Industry Organization 2020 台灣生物產業發展協會 第十六屆理事

•Member, Steering Committee, 16th&18th Outstanding Medical/Pharmaceutical Technology Award, Tien Te Lee Biomedical Foundation 2020,2022.第 16, 18屆永信李天德醫藥科技獎評審委員

•Reviewer, 24th National Chair Professor in Biology, Medicine and Agriculture, Ministry of Education. 2020-. 第24屆教育部國家講座主持人生物及醫農科學類評審委員

•Member, Academic Advisory Board (AAC), Institute of Molecular Biology, Academia Sinica, Taiwan. 2020-2025 中央研究院分子生物研究所 學術諮詢委員會

•Council Member, Green University Union of Taiwan. 2019-2021. 臺灣綠色大學聯盟第4屆理事

•Chair, Research committee of director of Institute of Molecular Biology, Academia Sinica. 2018-2020 中央研究院分子生物研究所 所長遴選委員會主席

Current Positions

•Chair Professor, Institute of Biological Science and Technology, National Chiao Tung University (2011－)

Education

•B.S., Department of Agronomy, National Taiwan University (1966-1967)

•B.S., Department of Agricultural Chemistry, National Taiwan University (1967-1970)

•M.S., Institute of Biochemistry, School of Medicine, National Taiwan University (1970-1972)

•Ph.D., Department of Biochemistry, University of Tennessee (1972-1976)

Professional Experience

•Post-doctoral, Department of Biochemistry, School of Medicine Georgetown University (1975-1979)

•Consultant, BRL Company, Bethesda, Maryland, USA (1978-1979)

•Associate Professor, Department and Institute of Biochemistry, National Yang-Ming Medical College (1979-1985)

•Acting Chairman, Institute of Biochemistry, National Yang-Ming Medical College (1984-1986)

•Professor, Institute of Biochemistry and Molecular Biology, National Yang-Ming University

•(1985-2011)

•Chairman, Institute of Biochemistry, National Yang-Ming University (1986-1991;1994-1997)

•Dean, Academic Affairs, National Yang-Ming University (1999-2001)

•Acting President, National Yang-Ming University (2000-2001, 2009.11-2010.7)

•President, National Yang-Ming University (2001-2009)

•Distinguished Chair Professor, National Yang-Ming University (2007-2011)

•Acting Chancellor, University System of Taiwan (2008-2012)

•Advisor, Yuan Science and Technology (2010-2011)

•Board Member, NHRI (2010-2012, 2013-2014, 2016-2019)

•Board Member, ITRI (2011-2016)

•Board Member, NARL (2012-2013)

•Board Member, Chung-Shan Institute of Science & Technology (2014-2017)

•Advisor, NARL, The White Paper on Science and Technology: A Preliminary Study (2014)

•President, National Chiao Tung University (2011-2015)

EDUCATION AND POSITIONS HELD:

• M.D., National Taiwan University, 1968

• M.S., Yale University, 1969

• Ph.D., Microbiology/Immunology, University of Chicago, 1973

• Assistant Professor through Professor of Pediatrics, University of California, San Diego, 1977-2001

• Professor and Chief, Pediatric Hematology/Oncology, University of California, San Diego, 2001-2003

• Distinguished Professor and Deputy Director, Genomics Research Center, Academia Sinica, 2003-2013

PRESENT TITLE AND AFFILIATION

Primary Appointment

．Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas

．MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

．Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of

．Texas MD Anderson Cancer Center, Houston, TX

．Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research,

．The University of Texas MD Anderson Cancer Center, Houston, TX

EXPERIENCE/SERVICE

Academic Appointments

．Assistant Clinical Instructor, Department of Head and Neck Surgery, University of Pennsylvania,

．School of Medicine, Philadelphia, PA, 7/1999-6/2001

．Clinical Instructor, Department of Head and Neck Surgery, University of Pennsylvania, School of Medicine, Philadelphia, PA, 7/2001-6/2003

．Instructor, Department of Head and Neck Surgery, University of Pittsburgh, School of Medicine,

．Pittsburgh, PA, 7/2003-6/2005

．Assistant Professor, Department of Otolaryngology, University of Pittsburgh, School of Medicine,

．Pittsburgh, PA, 7/2005-8/2008

．Assistant Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008-8/2010

．Assistant Professor, Department of Molecular and Cellular Oncology, The University of Texas

．MD Anderson Cancer Center, Houston, TX, 9/2008-8/2010

．Associate Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2010-8/2017

．Associate Professor, Department of Molecular and Cellular Oncology, Division of Basic Science

．Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2010-8/2017

．Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 8/2017-present

．Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research

．The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2017-present

．Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas

．MD Anderson Cancer Center, Houston, TX, 9/2017-present

Administrative Appointments/Responsibilities

．Faculty Senate Member, Faculty Senate, Division of Surgery, The University of Texas

．MD Anderson Cancer Center, Houston, TX, 2009-2015

．Patient Safety Quality Officer, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009-2021

Superintendent Office Superintendent Lung Cancer Attending Physician Department of Medical Oncology Attending Physician Basic and Clinical Oncology, Anticancer Drug Research and Development, Chemical Drug Resistance, Clinical Trials, New Anticancer Drug Development, Lung Cancer Immune Microenvironment.

Education

National Taiwan University	Graduate Institute of Clinical Medicine, College of Medicine	Ph.D.
National Taiwan University	School of Medicine, College of Medicine	M.D.

Current Positions

National Taiwan University Cancer Center	Superintendent	2020--present
Cancer Administration and Coordination Center, National Taiwan University Hospital	Director	2016--present
Graduate Institute of Oncology, College of Medicine, National Taiwan University	Director	2015--present
Graduate Institute of Oncology, College of Medicine, National Taiwan University	Professor	2009--present
The Ph.D. Program for Translational Medicine, College of Medicine, National Taiwan University	Professor	2012--present
Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University	Professor	2008--present
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University	Professor	2008--present
Department of Oncology, National Taiwan University Hospital	Adjunct Attending Physician	2020--present

Education

•1975.8 - 1982.7 M.D. Kaohsiung Medical College, Kaohsiung, Taiwan

•1992.8 – 2001.7 Ph.D. Post-graduate School, Kaohsiung Medical University

Current Position

•1988.08- Attending Physician, Division of Gastroenterology, Department of Medicine, Kaohsiung Medical University Hospital

•2012.08- Adjunct Professor of Internal Medicine, Medical School, National Cheng Kung University, Tainan, Taiwan

•2007.07- Attending Physician, Department of Internal Medicine, National Cheng-Kung University Hospital

•2014.08- Director, National Institute of Cancer Research, National Health Research Institutes

•2020.08- Co-affiliated, Distinguished Investigator, National Health Research Institutes

•2020.08- Chair Professor of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

•2020.08- Chief Executive Officer of Center for Cancer Research, Kaohsiung Medical University

•2020.08- Chairperson, Research and Development Committee, Kaohsiung Medical University Chung-Ho Memorial Hospital

Profile

• Over 14 years of R&D experience across biotech and academia in the areas of oncology, cell therapies, and immuno-oncology. Served for over several years in leadership roles including chief scientist and CEO. Co-founder of Acepodia, Inc.

• Track record in the discovery of cell therapy products and translation from pre-clinical candidates to FDA- approval phase, including bringing one of my own Berkeley research cell therapy drug candidate to get IND approval and to get into clinical trials in the US.

• Strong experience in advancing innovative and emerging technologies, such as NK cell therapy, gamma delta T cell therapy, antibody-cell conjugates, adoptive/CAR cell therapies (including donor-derived & cell line approaches).

• Leadership with expertise in building and leading teams across the entire spectrum of drug development, from initial discovery to IND and patent filing, safety, PK/PD, CMC, regulatory, and early-phase clinical trials. Experience in working in a fast-pace environment, including chairing high-level company committees responsible for making go or no-go decisions. Leading scientist with numerous publications and worldwide patent applications and issued patents

• Co-Founder and Chief Executive Officer at Acepodia, Inc. Awarded Dr. Y-T Lee Prize, which named after Nobel Laureate Dr. Lee, for the research achievement in Chemistry. Extensive research experiences in immune cell therapies, which lead to the discovery of ACC (Antibody-Cell Conjugation) technology, and to the invention of the novel cellular immunotherapy, ACE (Antibody-Cell Conjugation Effectors). BS in Chemistry from National Taiwan University, and PhD in Chemistry and Molecular Cell Biology from the University of California, Berkeley.

PROFESSIONAL EXPERIENCE

Acepodia, Inc.

Member of the Board of Directors, 2016 – Present

Founder and CEO, 2016 – Present

• Became CEO and President of Acepodia, Inc in 2016 at the operational inception of the company to build an innovative organization to develop new therapies in immune-oncology and cell therapy medicine.

• Recruited R&D team, developed company development strategy, and executed on a capital-efficient program to bring company’s lead product from lab research concept through completion of a development program comprising preclinical small animal and non-human primate studies in solid and liquid tumors.

• Helped the company built unique value by forging its path through a complex and largely unprecedented clinical, regulatory, and manufacture landscape.

Adheren, Inc.

Founder and Chief Scientific Officer, 2014 - 2015

• Chief Scientist of Adheren, Inc at the inception of the company with a focus on the interface of science and business value creation.

• Reported to the CEO and was member of both the Executive and Scientific Leadership teams with responsibility at various times for: R&D, Corporate Strategy, and Product Development.

• As a PI, I have demonstrated my ability to manage grants and the progress of experiments. I have managed and executed a NCI-IMAT R33 grant, and manage several collaborations with academic laboratories, including Robert Negrin and Everett Meyer labs at Stanford University, and David Schaffer lab at UC Berkeley.

University of California, Berkeley

Graduate Research Associate, 2007 – 2011

• Study and research of cell surface modification and protein/DNA conjugation chemistry.

abstract:

Writing the Future of Antibody Discovery with Synthetic DNA

Utilizing its proprietary DNA technology to write synthetic libraries, Twist Biopharma provides end-to-end antibody discovery libraries including both (1) highly diverse synthetic naïve antibody phage display libraries and (2) target class specific antibody phage display libraries against difficult-to-drug targets. The high throughput platform can chemically synthesize 1 million individual DNA oligos, each of them up to 300 base pairs, on a silicon chip that is roughly the same size as a smart phone. It is a game-changing throughput involves development of software, robotic, integrated ecommerce platform, and manufacture system. This silicon-based DNA synthesis platform can be applied and beneficial on various DNA products, including antibody discovery. With large collection of the libraries and high-speed production, we can obtain large variety of sequence for drug development.

• Experienced in Cell biology, Immuno-Oncology, Antibody drug discovery, Assay development

• High quality publications: 15 publications, 6 scientific presentations, 2 journal/press cover graphics, and 5 patents

• Project management and Team leading with strong organization and communication skills

RESERACH EXPERIENCE

Senior Staff Scientist, Head of Cell Biology	Oct. 2022 – Present
Senior Scientist	Oct. 2021 – Oct. 2022
Staff Scientist	Jun. 2020 – Sep. 2021

Twist Bioscience, Biopharma, CA, USA

• Lead multiple immune-oncology and GPCR projects from discovery to lead selection; Managing 2 scientists and 4 RAs.

• Lead four major projects proceed to pre-clinical phase; One licensed out to world-leading pharma

• Evaluate strategies and assay capabilities of revenue projects; Draft proposal and follow up financial milestone

• Design, implement and manage in vitro mechanism of action validation assays (e.g., FACS cell binding, ELISA, cell-based functional assays, primary immune cell assays, cytotoxicity assay, and design in vivo pre-clinical study)

• Effectively and timely communicate scientific interpretation to multi-disciplinary internal departments and external collaborators to deliver quality findings in support of drug candidate advancement

• Critical scientific/technical data analysis, experiments interpretation, and report presentation

• Establish team structure for lead characterization and stable cell line development workflow

• Validate the potency of bispecific antibodies and secondary ADC cell binding, viability and cytotoxicity assay

• Communicate with CRO for in vivo study, metabolic stability assay, PK study, and evaluate new partner collaboration

• Listed in 5 patents as an inventor, and 4 paper as an author; Presented in AACR and Keystone symposia as a speaker

Research Scientist

Jul. 2018 – May. 2020

AbVision Inc., Drug Discovery R&D Department, CA, USA

• Led novel immune checkpoint blockade antibody projects; Listed in 1 patent as an inventor

• Experienced in hybridoma fusion, positive clone screening, limited dilution, and subcloning

• Characterized therapeutic antibodies using ELISA, multi-color FACS, cell-based and primary cell functional assays; developed primary B cell, T cell, dendritic cell, and macrophage cell functional assays

• Established primary single B cell sorting platform for monoclonal antibody discovery

• Performed protein expression and purification using Expi293 and CHO expression system

• Developed cell therapy platform utilizing artificial APC for primary antigen-specific T cell activation and expansion

• Established cell line with lentiviral transduction for T cell activation assay

Postdoctoral Research Fellow, Lab Instructor

Feb. 2012 - Apr. 2018

University of Southern California, Molecular Microbiology and Immunology, CA, USA

• Led Virus research project: Regulation of Autophagy by Hepatitis C Virus for Its Replication

• Published 10 research articles with 3 presentations in International Symposium on Hepatitis C Virus

• Specialized in exceptional laboratory skills including mammalian cell culture, Western blotting, cell imaging, transfection for gene expression and siRNA knockdown

• Trained junior scientists to evaluate scientific literature, formulate independent research projects, and coherently communicate findings; resulting in obtaining international conference award

Research Associate

Jan. 2005 - Jan. 2012

Academia Sinica, Molecular Biology, Taiwan

• Supported external RNAi core facility and performed lentiviral-based gene silencing to buildup the shRNA database

• Performed plasmid cloning, PCR mutagenesis, RNA-protein interaction, electroporation, mass spectrometry, SEM